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The paper aims to analyze the challenges and opportunities for the implementation of industry 4.0 from the perspective of a public policy to encourage research, development and innovation (RD&I) from the Informatics Law (IL) in the Manaus Free Trade Zone (MFTZ). The theoretical foundation is initially carried out using the bibliographic and documental research method, based on a literature review on the main available knowledge scientific databases, using the terms “industry 4.0” and “research, development and innovation”, as well as the IL RD&I policy at MFTZ. The results are described in three dimensions: training and qualification of human resources, fostering the innovation ecosystem and RD&I.

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